Christian clergymen conduct a ceremony in the interior of Saint Peter's Grotto in Antioch.

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Historical Timeline of Antioch

Prehistory

The area of the later Antioch is a settlement called “Meroe.”

323 BC

Alexander the Great Dies

Alexander the Great dies and his generals, collectively called the Daidochi, divide up the territory he conquered. The general Seleucus I Nicator gets the territory of Syria.

300 BC

Antioch Founded by Seleucus I Nicator

Seleucus I Nicator, a general of the deceased Alexander the Great, founds Antioch as a Hellenistic Greek city. He names the city in honor of his father, Antiochus, who was also a general of Alexander the great. Seleucus founded 16 cities and called them all Antioch, so this one is called “Antioch on the Orontes” (on the Orontes River), to distinguish it from the others. Seleucus encourages Greeks from around the Mediterranean to settle in the new city.

63 BC

Romans Take Control

The Romans take control of Antioch and make it the capital of the Roman Province of Syria. Antioch thrives, becoming the third largest city in the Roman Empire after Rome and Alexandria. The Romans build or improve the roads, theater, baths aqueducts, add a hippodrome for chariot racing.

c. 36 AD

Peter, Paul, and Other Disciples Move to Antioch

Peter, the Apostle of Jesus, goes to Antioch and establishes the Church of Antioch, where Jesus’ followers are first called Christians. Antioch becomes the new center of Christianity. The Apostle Paul also lives there and uses it as a base for his missionary journeys. According to local lore, the Christians meet in a cave, today a museum called Saint Peter’s Grotto.

115 AD

Roman emperor Trajan visits Antioch

During Trajan’s time in Antioch, the city is shaken by a huge earthquake. The Emperor is forced to go to the hippodrome, which is unroofed, for his safety. The earthquake causes the population to shrink by 400,000 people. Trajan restores the city but much of it has been abandoned.

181 AD

Commodus Holds the Olympic Games to Antioch

Roman Emperor Commodus generously supports Antioch and builds a public bath, a xystos, and a covered running track, and begins holding the Olympic Games in Antioch. Commodus

252 AD

First Christian Church Assembly held at Antioch

The first of ten assemblies of the Christian church is held at Antioch. The assemblies will continue until 300 AD.

256 AD

Persians Attack Antioch

The Persians raid Antioch and kill some 100,000 people. The rest are taken as slaves.

327 AD

Constantine the Great Builds the Great Church of Antioch

The Great Church of Antioch serves for the next two centuries as the leading church of the city.

526 AD

Earthquake Hits Antioch and Seleucia Pieria

An earthquake severely damages Antioch and its nearby port city, Seleucia Pieria. Seleucia Pieria is already struggling with the silting of its harbor, and it will never recover.

528 AD

Another Earthquake Hits Antioch and Seleucia Pieria

After the earthquake Byzantine Emperor Justinian I restores many of its public buildings.

540 AD

Persians Attack and Deport the Population

Persian King Khosrau I deports 300,000 of the population to a new city he is building. Antioch’s decline is past the point of no return.

588 AD

Another Earthquake Hits Antioch and Seleucia Pieria

The Great Church of Antioch is destroyed.

613 AD

The Sasanians Take Antioch

The Byzantines, in a battle with the Persians just outside Antioch, are defeated. The Sasanians sack Antioch and take control of much of Syria and eastern Anatolia.

637 AD

Antioch Conquered by the Muslims

The Rashidun Caliphate, the first successors of Mohammed, sack Antioch. Muslim influence in Asia Minor begins. Antioch now serves as a military and administrative center for the Muslim army.

Travel writer Ken Grubb, with backpack, in Izmir, Türkiye.

Ken Grubb

Ken Grubb is an American travel writer, retired Special Investigator for the U.S. Air Force Office of Special Investigations (OSI), and former adjunct instructor for the University of Maryland at NATO bases in Izmir and at Incirlik Air Base, Türkiye. He’s a former managing partner of Turkey Central LLC, where he assisted people worldwide in visiting and living in Türkiye. Ken’s passion is the ancient Christian history of Türkiye and Greece, focusing on the places where the stories of the New Testament took place. He’s lived in Türkiye for more than 20 years.

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